Basic Information
VIS ID
TVIS10012913
Fusion event
HBV-chr21 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|
Start
2876
Orient
+
Integrated sequence
TTATATAAGAGAGAAACAACACATAGCGCCTCATTTTGTGGGTCACCATATTCTTGGGAACAAGATCTACAGCATGGGGCAGAATCTTTCCACCAGCAAT| |CCTCTGGGATTCTTTCCCGACCACCAGTTGGATCCAGCCTTCAGAGCAAACACCGCAAATCCAGATTGGGACTTCAATCCCAACAAGGACACCTGGCCAG
Host Sequence
Chromosome
chr21
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
10878715/10633740 (Hg38)
End
10878715/10633740 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-10396a/Upstream/1646075; hsa-let-7c/Downstream/2772644;
Nearest TSS
ENST00000624081/Upstream/112165; ENST00000624445/Downstream/16095;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/6016, chr21-CpG: 39/Downstream/2975875
Nearby gene
TEKT4P2(-910122) ; TPTE(+28028) ;
Upstream sequence
tttacatttgctgaggagtgctttacttccaactatgtggtcagttttggagtaagtgcggtgtggtgctgaaagaatgtatattctgttgatttggcat
Downstream sequence
agagagttctgtagatgtctattatgtctgcttggtgcagagctgagttcaattcctggatatccttgttaactttctgtctcgttgatctgtctaatgt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate