Basic Information
VIS ID
TVIS10012916
Fusion event
HBV-chr21 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
2478
Orient
-
Integrated sequence
AACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAGGTGGG| |GAACTTTACTGGGCTTTATTCTTCTACTGTACCTGTCTTTAATCCTCATTGGAAAACACCATCTTTTCCTAATATACATTTACACCAAGACATTATCAAA
Host Sequence
Chromosome
chr21
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
19800394/18428077 (Hg38)
End
19800394/18428077 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-let-7c/Upstream/1837752; hsa-mir-155/Downstream/258013;
Nearest TSS
ENST00000624081/Upstream/24421; ENST00000416002/Downstream/32654;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/182520, chr21-CpG: 89/Downstream/2569028
Nearby gene
TMPRSS15(-24424) ;
Upstream sequence
GAAAGAACCATTATTTCTCCAGCAATAGAGATGTTTTTAATTGACCGACAGAAGTCTTTTGCTCAATGAAGAGTTACAATGGGAAACTTCTTTTCACTAA
Downstream sequence
TCTCCTGGGTTATTATTAATTATTGATATTACTTAACAATTAAAAATTCTGCAAGATATGAAGCCTTTCTTTTAGAATTGTTTAAAGGCAAGACAACAAA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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