Basic Information
VIS ID
TVIS10012918
Fusion event
HBV-chr3 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|
Start
2926
Orient
+
Integrated sequence
TTCTTGGGAACAAGATCTACAGCATGGGGCAGAATCTTTCCACCAGCAATCCTCTGGGATTCTTTCCCGACCACCAGTTGGATCCAGCCTTCAGAGCAAA| |CACCGCAAATCCAGATTGGGACTTCAATCCCAACAAGGACACCTGGCCAGACGCCAACAAGGTAGGAGCTGGAGCATTCGGGCTGGGTTTCACCCCACCG
Host Sequence
Chromosome
chr3
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
122454399/122735552 (Hg38)
End
122454399/122735552 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-let-7g/Upstream/1685837; hsa-mir-12124/Downstream/426242;
Nearest TSS
ENST00000440867/Upstream/17168; ENST00000477647/Downstream/6224;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/54209, chr3-CpG: 28/Downstream/58086
Nearby gene
PARP14(-4712) ; HSPBAP1(+4445) ;
Upstream sequence
attgtaaattttaaaataaataaaaaattgtaattggattatttataacacaaaggataaatgcttgaatggatgatacctcattttccatgatgtgatt
Downstream sequence
tcaacagaatatacatttttttcagcaccacaccacacctattccaaaattgaccacatagttggaagtaaagcactcctcagcaaatgtaaaagaacag
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate