VISDB Viral Integration Site DataBase

VIS ID

TVIS10012920

Fusion event

HBV-IGSF10 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

Polymerase|large S protein|

Start

2899

Orient

+

Integrated sequence

TAGCGCCTCATTTTGTGGGTCACCATATTCTTGGGAACAAGATCTACAGCATGGGGCAGAATCTTTCCACCAGCAATCCTCTGGGATTCTTTCCCGACCA| |CCAGTTGGATCCAGCCTTCAGAGCAAACACCGCAAATCCAGATTGGGACTTCAATCCCAACAAGGACACCTGGCCAGACGCCAACAAGGTAGGAGCTGGA

Chromosome

chr3

Cytoband

q25.1

Reference genome

Start

End

151229953/151512165 (Hg38)

Orient

-

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-335-5p ; hsa-mir-148b-3p ; hsa-mir-518a-5p ; hsa-mir-527 ; hsa-mir-548aw ; hsa-mir-578 ; hsa-mir-627-3p

Nearest miRNA

hsa-let-7g/Upstream/17074259; hsa-mir-1224/Downstream/53711;

Nearest TSS

Nearest CpG islands

None/Target, chr3-CpG: 148/Upstream/424784, chr3-CpG: 92/Downstream/756373

Nearby gene

IGSF10(-53456) ; MIR5186(+53711) ;

Upstream sequence

atggatgatacctcattttccatgatgtgattatcacgcattgcatgcttctatcaaaacatttcatgtactccataagtatatacacttacgatatatc

Downstream sequence

tttcaacaccacaccacacctattccaaaattgaccacatagttggaagtaaagcactcctcagcaaatgtaaaagaacagaaattataataaactctct