Basic Information
VIS ID
TVIS10012922
Fusion event
HBV-chr3 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|
Start
2910
Orient
+
Integrated sequence
TTTGTGGGTCACCATATTCTTGGGAACAAGATCTACAGCATGGGGCAGAATCTTTCCACCAGCAATCCTCTGGGATTCTTTCCCGACCACCAGTTGGATC| |CAGCCTTCAGAGCAAACACCGCAAATCCAGATTGGGACTTCAATCCCAACAAGGACACCTGGCCAGACGCCAACAAGGTAGGAGCTGGAGCATTCGGGCT
Host Sequence
Chromosome
chr3
Cytoband
p24.1
Reference genome
GRCh37/hg19
Start
26429605/26388114 (Hg38)
End
26429605/26388114 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA3A
Nearest miRNA
hsa-mir-12127/Upstream/723175; hsa-let-7g/Downstream/4773590;
Nearest TSS
ENST00000440867/Upstream/597093; ENST00000469437/Downstream/234576;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/597961, chr3-CpG: 71/Downstream/234499
Nearby gene
LINC00692(-514419) ; LRRC3B(+234695) ;
Nearest cancer related gene
LRRC3B(TSG, +234695) ;
Upstream sequence
CTCCAGCCTTGAGATAATCTGATTTAGAGACTGATTTGTGAAGTTCATTGGCCTTAAATAATTGAAATAGTCAGTGCTGCTCTTGTAATAACTTTCACTT
Downstream sequence
taatttctgttcttttacatttgctgaggagagctttacttccaactatgtggtcaattttggaataggtgtggtgtggtgttgaaaaaaatgtatattc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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