Basic Information
VIS ID
TVIS10012925
Fusion event
HBV-LOC105377094 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|
Start
2892
Orient
+
Integrated sequence
CAACACATAGCGCCTCATTTTGTGGGTCACCATATTCTTGGGAACAAGATCTACAGCATGGGGCAGAATCTTTCCACCAGCAATCCTCTGGGATTCTTTC| |CCGACCACCAGTTGGATCCAGCCTTCAGAGCAAACACCGCAAATCCAGATTGGGACTTCAATCCCAACAAGGACACCTGGCCAGACGCCAACAAGGTAGG
Host Sequence
Chromosome
chr3
Cytoband
p21.1
Reference genome
GRCh37/hg19
Start
53402713/53368686 (Hg38)
End
53402713/53368686 (Hg38)
Orient
+
Location type
Intronic
Target gene
LOC105377094
Nearest miRNA
hsa-let-7g/Upstream/522134; hsa-mir-12124/Downstream/2483806;
Nearest TSS
ENST00000440867/Upstream/21076; ENST00000636480/Downstream/125970;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/20777, chr3-CpG: 206/Downstream/125214
Nearby gene
DCP1A(-21059) ; CACNA1D(+126318) ;
Upstream sequence
ggtttcgccgtattgcccagcctggtctcgatcgcatggctcaagcaatctgcctgcctcagcctcccaaagtgcttggattacaagcatgagttactgc
Downstream sequence
ttacatttgctgaggagagctttacttccaactatgtggtcaattttggaataggtgtggtgtggtgttgaaaaaaatgtatattctgttgatttggggt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate