Basic Information
VIS ID
TVIS10012926
Fusion event
HBV-chr3 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|
Start
2876
Orient
+
Integrated sequence
TTATATAAGAGAGAAACAACACATAGCGCCTCATTTTGTGGGTCACCATATTCTTGGGAACAAGATCTACAGCATGGGGCAGAATCTTTCCACCAGCAAT| |CCTCTGGGATTCTTTCCCGACCACCAGTTGGATCCAGCCTTCAGAGCAAACACCGCAAATCCAGATTGGGACTTCAATCCCAACAAGGACACCTGGCCAG
Host Sequence
Chromosome
chr3
Cytoband
p14.1
Reference genome
GRCh37/hg19
Start
65042026/65056351 (Hg38)
End
65042026/65056351 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-let-7g/Upstream/4438481; hsa-mir-12124/Downstream/2169113;
Nearest TSS
ENST00000440867/Upstream/368351; ENST00000481004/Downstream/118607;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/368070, chr3-CpG: 63/Downstream/300177
Nearby gene
ADAMTS9-AS2(-44883) ; MAGI1(+297880) ;
Nearest cancer related gene
ADAMTS9-AS2(TSG, -44883) ;
Upstream sequence
gcctaattttgtatttttagtagagacggagcttctccatgttggtcacctgctcttgaactcccaacctcaggtgatctgcccgcctcagactcccaaa
Downstream sequence
tctgcaccaagcagacataatagacatctacagaactttccacaccaaatcaacagaatatacattcttctcagcaccacatcacacctattccaaaact
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate