Basic Information
VIS ID
TVIS10012927
Fusion event
HBV-LINC02027 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|
Start
2876
Orient
+
Integrated sequence
TTATATAAGAGAGAAACAACACATAGCGCCTCATTTTGTGGGTCACCATATTCTTGGGAACAAGATCTACAGCATGGGGCAGAATCTTTCCACCAGCAAT| |CCTCTGGGATTCTTTCCCGACCACCAGTTGGATCCAGCCTTCAGAGCAAACACCGCAAATCCAGATTGGGACTTCAATCCCAACAAGGACACCTGGCCAG
Host Sequence
Chromosome
chr3
Cytoband
p12.2
Reference genome
GRCh37/hg19
Start
81103925/81054774 (Hg38)
End
81103925/81054774 (Hg38)
Orient
+
Location type
Intronic
Target gene
LINC02027
Nearest miRNA
hsa-let-7g/Upstream/1546805; hsa-mir-12124/Downstream/4330936;
Nearest TSS
ENST00000440867/Upstream/60906; ENST00000471614/Downstream/154140;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/1288024, chr3-CpG: 75/Downstream/706390
Nearby gene
ROBO1(-1286866) ; GBE1(+434925) ;
Upstream sequence
AGAATTGGAATTCAAAGTGGACCAAAAAGTGTAATAGAAAAAAAAAAGTATGAAAGGAAACCTGAAATTGTTCTACGATGCTTGCTTTGTTTTAACGGAA
Downstream sequence
atttctgttcttttacatttgctgaggagagctttacttccaactatgtggtcaattttggaataggtgtggtgtggtgttgaaaaaaatgtatattctg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate