Basic Information
VIS ID
TVIS10012930
Fusion event
HBV-LOC107986178 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|
Start
2876
Orient
+
Integrated sequence
TTATATAAGAGAGAAACAACACATAGCGCCTCATTTTGTGGGTCACCATATTCTTGGGAACAAGATCTACAGCATGGGGCAGAATCTTTCCACCAGCAAT| |CCTCTGGGATTCTTTCCCGACCACCAGTTGGATCCAGCCTTCAGAGCAAACACCGCAAATCCAGATTGGGACTTCAATCCCAACAAGGACACCTGGCCAG
Host Sequence
Chromosome
chr4
Cytoband
p15.33
Reference genome
GRCh37/hg19
Start
11582535/11580911 (Hg38)
End
11582535/11580911 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA4D
Target gene
LOC107986178
Nearest miRNA
hsa-mir-3138/Upstream/211990; hsa-mir-12113/Downstream/202267;
Nearest TSS
ENST00000502981/Upstream/111661; ENST00000508998/Downstream/44803;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/151279, chr4-CpG: 97/Downstream/1902987
Nearby gene
HS3ST1(-151998) ; HSP90AB2P(+1752502) ;
Upstream sequence
aaaaaattagccaggcgtggtggtgggcacctgtactcccagctactcaggaggctgaggcaggagaatggcatgaaccagggaggcagagcttgcagtg
Downstream sequence
gagttcaattcctgagtatccttgttaactttctgtctcattgatctgtctaatgttgacagtgggttgttaaagtctcccattattaatgtgtgggagt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate