Basic Information
VIS ID
TVIS10012932
Fusion event
HBV-LOC107986194 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|
Start
2929
Orient
+
Integrated sequence
TTGGGAACAAGATCTACAGCATGGGGCAGAATCTTTCCACCAGCAATCCTCTGGGATTCTTTCCCGACCACCAGTTGGATCCAGCCTTCAGAGCAAACAC| |CGCAAATCCAGATTGGGACTTCAATCCCAACAAGGACACCTGGCCAGACGCCAACAAGGTAGGAGCTGGAGCATTCGGGCTGGGTTTCACCCCACCGCAC
Host Sequence
Chromosome
chr4
Cytoband
q31.21
Reference genome
GRCh37/hg19
Start
143914706/142993553 (Hg38)
End
143914706/142993553 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC107986194
Nearest miRNA
hsa-mir-12113/Upstream/17486246; hsa-mir-1305/Downstream/349907;
Nearest TSS
ENST00000502981/Upstream/146121; ENST00000510377/Downstream/191276;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/146293, chr4-CpG: 99/Downstream/190978
Nearby gene
INPP4B(-147102) ; USP38(+191364) ;
Upstream sequence
atatttgtactagcatgatattagtgttccagttgctgctcatccctgctgacacttgatatggccagtctttttaactttagccatttttgtagatata
Downstream sequence
caccccaaatcaacagaatatacatttttttcagcaccacaccacacctattccaaaattgaccacatagttggaagtaaagcactcctcagcaaatgta
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate