Basic Information
VIS ID
TVIS10012935
Fusion event
HBV-chr4 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|
Start
2876
Orient
+
Integrated sequence
TTATATAAGAGAGAAACAACACATAGCGCCTCATTTTGTGGGTCACCATATTCTTGGGAACAAGATCTACAGCATGGGGCAGAATCTTTCCACCAGCAAT| |CCTCTGGGATTCTTTCCCGACCACCAGTTGGATCCAGCCTTCAGAGCAAACACCGCAAATCCAGATTGGGACTTCAATCCCAACAAGGACACCTGGCCAG
Host Sequence
Chromosome
chr4
Cytoband
q12
Reference genome
GRCh37/hg19
Start
57200767/56334601 (Hg38)
End
57200767/56334601 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA4B
Nearest miRNA
hsa-mir-12113/Upstream/3621854; hsa-mir-1243/Downstream/4588018;
Nearest TSS
ENST00000502981/Upstream/17938; ENST00000602927/Downstream/49698;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/18620, chr4-CpG: 33/Downstream/52701
Nearby gene
KIAA1211(-3877) ; AASDH(+3690) ;
Upstream sequence
ttttctgtgggatacaacatttatttatttatttatttatttagagacagagtctcgctctgttgcccatgctggagtgcagtggcgctatcttggctca
Downstream sequence
gtctgagagacagtttgttataatttctgttcttttacatttgctgaggagtgctttacttccaactatgtggtcaattttggaataggtgtggtgtggt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate