Basic Information
VIS ID
TVIS10012942
Fusion event
HBV-chr4 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|
Start
2893
Orient
+
Integrated sequence
AACACATAGCGCCTCATTTTGTGGGTCACCATATTCTTGGGAACAAGATCTACAGCATGGGGCAGAATCTTTCCACCAGCAATCCTCTGGGATTCTTTCC| |CGACCACCAGTTGGATCCAGCCTTCAGAGCAAACACCGCAAATCCAGATTGGGACTTCAATCCCAACAAGGACACCTGGCCAGACGCCAACAAGGTAGGA
Host Sequence
Chromosome
chr4
Cytoband
q13.3
Reference genome
GRCh37/hg19
Start
71286979/70421262 (Hg38)
End
71286979/70421262 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-12113/Upstream/4144334; hsa-mir-1243/Downstream/6152306;
Nearest TSS
ENST00000502981/Upstream/23297; ENST00000515308/Downstream/9230;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/2071059, chr4-CpG: 55/Downstream/266875
Nearby gene
OPRPN(-11065) ; MUC7(+9230) ;
Upstream sequence
atatctacccaaagggaaataagtcattacatcaaaaagacacctacatgcatctgtttattgcagcacaatttcaaagatatggaaccaatctaagtac
Downstream sequence
tctgagagacagtttgttataatttctgttcttttacatttgctgaggagtgctttacttccaactatgtggtcaattttggaataggtgtggtgtggtg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate