Basic Information
VIS ID
TVIS10012946
Fusion event
HBV-chr5 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|
Start
2876
Orient
+
Integrated sequence
TTATATAAGAGAGAAACAACACATAGCGCCTCATTTTGTGGGTCACCATATTCTTGGGAACAAGATCTACAGCATGGGGCAGAATCTTTCCACCAGCAAT| |CCTCTGGGATTCTTTCCCGACCACCAGTTGGATCCAGCCTTCAGAGCAAACACCGCAAATCCAGATTGGGACTTCAATCCCAACAAGGACACCTGGCCAG
Host Sequence
Chromosome
chr5
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
106110058/106774357 (Hg38)
End
106110058/106774357 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA5F
Nearest miRNA
hsa-mir-10397/Upstream/5957792; hsa-mir-103a-1/Downstream/3739472;
Nearest TSS
ENST00000502646/Upstream/1381387; ENST00000513676/Downstream/206512;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/3514508, chr5-CpG: 253/Downstream/895072
Nearby gene
RAB9BP1(-1674259) ; EFNA5(+602532) ;
Nearest cancer related gene
EFNA5(TSG, +602532) ;
Upstream sequence
gttatctctcttgttccctaaacattgctgttatcctgttcttttttcaaggtgcccacatttcatattgttcaaacacacatgctctacaaacaatttg
Downstream sequence
atttctgttcttttacatttgctgaggagagctttacttccaactatgtggtcaattttggaataggtgtggtgtggtgttgaaaaaaatgtatattctg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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