Basic Information
VIS ID
TVIS10012952
Fusion event
HBV-chr5 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|
Start
2907
Orient
+
Integrated sequence
CATTTTGTGGGTCACCATATTCTTGGGAACAAGATCTACAGCATGGGGCAGAATCTTTCCACCAGCAATCCTCTGGGATTCTTTCCCGACCACCAGTTGG| |ATCCAGCCTTCAGAGCAAACACCGCAAATCCAGATTGGGACTTCAATCCCAACAAGGACACCTGGCCAGACGCCAACAAGGTAGGAGCTGGAGCATTCGG
Host Sequence
Chromosome
chr5
Cytoband
q31.3
Reference genome
GRCh37/hg19
Start
144206300/144826737 (Hg38)
End
144206300/144826737 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-10397/Upstream/1146766; hsa-mir-103a-1/Downstream/4235576;
Nearest TSS
ENST00000502646/Upstream/621460; ENST00000512571/Downstream/402245;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/227816, chr5-CpG: 43/Downstream/1008349
Nearby gene
KCTD16(-349356) ; PRELID2(+932282) ;
Upstream sequence
CCGGATGAGGATAAGGGGGGACTACTGTATACACACCGGATGAGGATAAGGGGGGACTACTGTAGACACACCGGATAAGGGGGGACTACTGTATACACAC
Downstream sequence
catttgctgaggagtgctttacttccaactatgtggtcaattttggaataggtgtggtgtggtgctgaaaaaaatgtatattctgttgatttggggtgga
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate