VISDB Viral Integration Site DataBase

VIS ID

TVIS10012955

Fusion event

HBV-LHFPL2 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

Polymerase|large S protein|

Start

2876

Orient

+

Integrated sequence

TTATATAAGAGAGAAACAACACATAGCGCCTCATTTTGTGGGTCACCATATTCTTGGGAACAAGATCTACAGCATGGGGCAGAATCTTTCCACCAGCAAT| |CCTCTGGGATTCTTTCCCGACCACCAGTTGGATCCAGCCTTCAGAGCAAACACCGCAAATCCAGATTGGGACTTCAATCCCAACAAGGACACCTGGCCAG

Chromosome

chr5

Cytoband

q14.1

Reference genome

Start

End

77878640/78582817 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-375 ; hsa-mir-221-3p ; hsa-mir-93-5p ; hsa-mir-32-5p ; hsa-let-7e-5p ; hsa-let-7a-5p ; hsa-mir-9-5p ; hsa-mir-588 ; hsa-mir-4701-5p ; hsa-mir-125b-2-3p ; hsa-mir-568 ; hsa-mir-1277-5p ; hsa-mir-3924 ; hsa-mir-1228-3p ; hsa-mir-1306-5p ; hsa-mir-374a-5p ; hsa-mir-297 ; hsa-mir-223-5p ; hsa-mir-567 ; hsa-mir-581 ; hsa-mir-5692c ; hsa-mir-5692b ; hsa-mir-369-3p ; hsa-mir-5580-3p ; hsa-mir-374b-5p ; hsa-mir-4263 ; hsa-mir-6753-3p ; hsa-mir-7107-3p ; hsa-mir-6758-5p ; hsa-mir-6856-5p ; hsa-mir-137 ; hsa-mir-92b-3p ; hsa-mir-92a-3p ; hsa-mir-367-3p ; hsa-mir-25-3p ; hsa-mir-363-3p ; hsa-mir-3692-3p ; hsa-mir-874-3p ; hsa-mir-3157-3p ; hsa-mir-1260b ; hsa-mir-1260a ; hsa-mir-6886-3p ; hsa-mir-938 ; hsa-mir-532-3p ; hsa-mir-6832-3p ; hsa-mir-1224-3p ; hsa-mir-758-3p ; hsa-mir-6808-3p ; hsa-mir-943 ; hsa-mir-623 ; hsa-mir-6820-3p ; hsa-mir-3164 ; hsa-mir-3118 ; hsa-mir-134-5p ; hsa-mir-4685-3p ; hsa-mir-6780b-3p ; hsa-mir-4287 ; hsa-mir-4780 ; hsa-mir-216b-3p ; hsa-mir-224-5p ; hsa-mir-30d-5p ; hsa-mir-30e-5p ; hsa-mir-30c-5p ; hsa-mir-30b-5p ; hsa-mir-30a-5p

Nearest miRNA

hsa-mir-10397/Upstream/5704154; hsa-mir-103a-1/Downstream/4257338;

Nearest TSS

Nearest CpG islands

None/Target, chr5-CpG: 87/Upstream/72327, chr5-CpG: 135/Downstream/65228

Upstream sequence

TAAGGGGGGACTACTGTATACACATTGGATGAGGATAAGGGGGGACTATTGTATACACACCAGATGAGGATAAGGGGGGACTACTGTATACACACCAGAT

Downstream sequence

tgagttcaattcctgggtatccttgttgactttctgtctcgttgatctgtccaatgttgacagtgggctgttgaagtctcccattattaatgtgtgggag