Basic Information
VIS ID
TVIS10012956
Fusion event
HBV-LINC02144 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
246
Orient
-
Integrated sequence
TGCGCTGAACATGGAGAACATCACATCAGGATTCCTAGGACCCCTTCTCGTGTTACAGGCGGGGTTTTTCTTGTTGACAAGAATCCTCACAATACCGCAG| |AGTCTAGACTCGTGGTGGACTTCTCTCAATTTTCTAGGGGGAACTACCGTGTGTCTTGGCCAAAATTCGCAGTCCCCAACCTCCAATCACTCACCAACCT
Host Sequence
Chromosome
chr5
Cytoband
q14.3
Reference genome
GRCh37/hg19
Start
86979814/87683997 (Hg38)
End
86979814/87683997 (Hg38)
Orient
-
Location type
Intronic
Target gene
LINC02144
Nearest miRNA
hsa-mir-10397/Upstream/569043; hsa-mir-103a-1/Downstream/982856;
Nearest TSS
ENST00000502646/Upstream/21955; ENST00000504636/Downstream/49272;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/270936, chr5-CpG: 30/Downstream/457281
Nearby gene
CCNH(-270964) ; TMEM161B(+511209) ;
Upstream sequence
TCataatatactcattaagcccccaccctttggggttaggcagtcctgtatgcaaatcctcattctgttactctgttattagctgatttgggataagtta
Downstream sequence
TCACATCTCTCTCAATGTACCCAGTCCCTCATCATTCCAACTTCATCAGGGTCCTGGCAGCATTGTGTTATCTACTCAGTGGCTCACACCACTCTCTCTC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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