Basic Information
VIS ID
TVIS10012967
Fusion event
HBV-chr7 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|
Start
2892
Orient
+
Integrated sequence
CAACACATAGCGCCTCATTTTGTGGGTCACCATATTCTTGGGAACAAGATCTACAGCATGGGGCAGAATCTTTCCACCAGCAATCCTCTGGGATTCTTTC| |CCGACCACCAGTTGGATCCAGCCTTCAGAGCAAACACCGCAAATCCAGATTGGGACTTCAATCCCAACAAGGACACCTGGCCAGACGCCAACAAGGTAGG
Host Sequence
Chromosome
chr7
Cytoband
p14.1
Reference genome
GRCh37/hg19
Start
42623558/42583959 (Hg38)
End
42623558/42583959 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-1183/Upstream/5664527; hsa-mir-10399/Downstream/566936;
Nearest TSS
ENST00000635602/Upstream/346089; ENST00000432845/Downstream/122488;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/90275, chr7-CpG: 74/Downstream/327658
Nearby gene
GLI3(-346940) ; C7orf25(+325314) ;
Nearest cancer related gene
GLI3(OG, -346940) ;
Upstream sequence
TATACTCATTTCTACCAGTAAGATTTTCTGGCTGCACATTTTCAAATACAGTCAACTTTTTCTTGCTCATATGCTAACCGGCATTCAGTCTTTTATAGCA
Downstream sequence
ttacatttgctgaggagtgctttacttccaactatgtggtcaattttggaataggtgtggtgtggtgctgaaaaaaatgtatattctgttgatttggggt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate