Basic Information
VIS ID
TVIS10012976
Fusion event
HBV-chr8 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
2480
Orient
+
Integrated sequence
CTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAGGTGGGGA| |ACTTTACTGGGCTTTATTCTTCTACTGTACCTGTCTTTAATCCTCATTGGAAAACACCATCTTTTCCTAATATACATTTACACCAAGACATTATCAAAAA
Host Sequence
Chromosome
chr8
Cytoband
p11.1
Reference genome
GRCh37/hg19
Start
43828692/43973549 (Hg38)
End
43828692/43973549 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-124-1/Upstream/1077274; hsa-mir-10400/Downstream/17741239;
Nearest TSS
ENST00000518652/Upstream/777381; ENST00000518278/Downstream/2848688;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/696214, chr8-CpG: 41/Downstream/2643818
Nearby gene
POTEA(-610364) ;
Upstream sequence
tagccagaagcattctaagaaacatcttagggatgtttacattcaagtcacagagttgaacattccctttcacagagcaggtttgaaacaatcttctcgt
Downstream sequence
tactatctggcagtggacattttgagctccttggggcctatgctgaaaaaggaaatatattccgacaaaaactagacagaggcattcgcagaatcacgtt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate