Basic Information
VIS ID
TVIS10013003
Fusion event
HBV-PLPPR1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|
Start
2910
Orient
+
Integrated sequence
TTTGTGGGTCACCATATTCTTGGGAACAAGATCTACAGCATGGGGCAGAATCTTTCCACCAGCAATCCTCTGGGATTCTTTCCCGACCACCAGTTGGATC| |CAGCCTTCAGAGCAAACACCGCAAATCCAGATTGGGACTTCAATCCCAACAAGGACACCTGGCCAGACGCCAACAAGGTAGGAGCTGGAGCATTCGGGCT
Host Sequence
Chromosome
chr9
Cytoband
q31.1
Reference genome
GRCh37/hg19
Start
103867805/101105523 (Hg38)
End
103867805/101105523 (Hg38)
Orient
+
Location type
Intronic
Target gene
PLPPR1
Nearest miRNA
hsa-let-7a-1/Upstream/2876306; hsa-mir-12126/Downstream/5495405;
Nearest TSS
ENST00000422679/Upstream/76814; ENST00000494890/Downstream/25999;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/76041, chr9-CpG: 49/Downstream/293048
Upstream sequence
atcagtcctcttcaattagggcatgaacaaggttaattttttgctcacaaattggagtggatggcttgccactgcaggcctcatcttcaacatcatcttg
Downstream sequence
taatttctgttcttttacatttgctgaggagagctttacttccaactatgtggtcaattttggaataggtgtggtgtggtgttgaaaaaaatgtatattc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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