Basic Information
VIS ID
TVIS10013004
Fusion event
HBV-PLPPR1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|
Start
2937
Orient
+
Integrated sequence
AAGATCTACAGCATGGGGCAGAATCTTTCCACCAGCAATCCTCTGGGATTCTTTCCCGACCACCAGTTGGATCCAGCCTTCAGAGCAAACACCGCAAATC| |CAGATTGGGACTTCAATCCCAACAAGGACACCTGGCCAGACGCCAACAAGGTAGGAGCTGGAGCATTCGGGCTGGGTTTCACCCCACCGCACGGAGGCCT
Host Sequence
Chromosome
chr9
Cytoband
q31.1
Reference genome
GRCh37/hg19
Start
104055744/101293462 (Hg38)
End
104055744/101293462 (Hg38)
Orient
-
Location type
Intronic
Target gene
PLPPR1
Nearest miRNA
hsa-let-7a-1/Upstream/3064245; hsa-mir-12126/Downstream/5307466;
Nearest TSS
ENST00000422679/Upstream/23660; ENST00000615466/Downstream/78013;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/263980, chr9-CpG: 49/Downstream/105109
Upstream sequence
cctatgcctgtctttgctctaatcttaatcccgtcaacttcgtaagcagaggaggatgtatgtcacctcaggaccctgtgatgattgcattaactgcaca
Downstream sequence
tctacagaactctccaccccaaatcaacagaatatacatttttttcagccccacaccacacctattccaaaattgaccacatagttggaagtaaagctct
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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