Basic Information
VIS ID
TVIS10013005
Fusion event
HBV-LOC105375999 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|
Start
2876
Orient
+
Integrated sequence
TTATATAAGAGAGAAACAACACATAGCGCCTCATTTTGTGGGTCACCATATTCTTGGGAACAAGATCTACAGCATGGGGCAGAATCTTTCCACCAGCAAT| |CCTCTGGGATTCTTTCCCGACCACCAGTTGGATCCAGCCTTCAGAGCAAACACCGCAAATCCAGATTGGGACTTCAATCCCAACAAGGACACCTGGCCAG
Host Sequence
Chromosome
chr9
Cytoband
p21.2
Reference genome
GRCh37/hg19
Start
26446178/26446180 (Hg38)
End
26446178/26446180 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA9C
Target gene
LOC105375999
Nearest miRNA
hsa-mir-101-2/Upstream/4933995; hsa-let-7a-1/Downstream/2417446;
Nearest TSS
ENST00000422679/Upstream/379505; ENST00000523363/Downstream/300773;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/767494, chr9-CpG: 69/Downstream/446110
Nearby gene
LOC100506422(-327772) ; CAAP1(+394505) ;
Upstream sequence
agcaggtcatgacacaggcagaaaactagaggaatgtggtgtcgccaaagcaagtgaagattgtttactaaggtaagagggaatgatcaactacgttaat
Downstream sequence
tctgcaccaagcagacccaatagacatctacagaactctccaccccaaatcaacagaatatacatctttttcatcaccacacctattgcaaaattgacca
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate