Basic Information
VIS ID
TVIS10013006
Fusion event
HBV-PHF24 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
601
Orient
-
Integrated sequence
ACCAGCACGGGACCATGCCGGACCTGCATGACTACTGCTCAAGGAACCTCTATGTATCCCTCCTGTTGCTGTACCAAACCTTCGGACGGAAATTGCACCT| |GTATTCCCATCCCATCATCCTGGGCTTTCGGAAAATTCCTATGGGAGTGGGCCTCAGCCCGTTTCTCCTGGCTCAGTTTACTAGTGCCATTTGTTCAGTG
Host Sequence
Chromosome
chr9
Cytoband
p13.3
Reference genome
GRCh37/hg19
Start
34935161/34935164 (Hg38)
End
34935161/34935164 (Hg38)
Orient
-
Location type
Intronic
Target gene
PHF24
miRNAs that regulate target gene
hsa-mir-26b-5p
Nearest miRNA
hsa-mir-101-2/Upstream/1467229; hsa-let-7a-1/Downstream/672930;
Nearest TSS
ENST00000422679/Upstream/39386; ENST00000486477/Downstream/22444;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/124932, chr9-CpG: 93/Downstream/22556
Nearby gene
FAM205BP(-96578) ; PHF24(+23031) ;
Upstream sequence
tcccaggttcaagcaattctcatgcctcagcctccagagtagctgggattacaggcatgtgccaccatgcccagctacttttttgtgttttttctagaga
Downstream sequence
gaggacatgtaagatgtggattgagaactgaatcctggatttcataacttgaaggccactggggacctttacaagacccttctcagtggaagggtaggaa
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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