Basic Information
VIS ID
TVIS10013007
Fusion event
HBV-chr9 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|
Start
2937
Orient
+
Integrated sequence
AAGATCTACAGCATGGGGCAGAATCTTTCCACCAGCAATCCTCTGGGATTCTTTCCCGACCACCAGTTGGATCCAGCCTTCAGAGCAAACACCGCAAATC| |CAGATTGGGACTTCAATCCCAACAAGGACACCTGGCCAGACGCCAACAAGGTAGGAGCTGGAGCATTCGGGCTGGGTTTCACCCCACCGCACGGAGGCCT
Host Sequence
Chromosome
chr9
Cytoband
p24.2
Reference genome
GRCh37/hg19
Start
3619160/3619160 (Hg38)
End
3619160/3619160 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-1302-9/Upstream/3588879; hsa-let-7a-1/Downstream/1231137;
Nearest TSS
ENST00000422679/Upstream/92437; ENST00000430387/Downstream/28175;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/92215, chr9-CpG: 69/Downstream/498665
Nearby gene
RFX3(-93177) ; GLIS3(+204968) ;
Upstream sequence
CTTCATGGTGACAGGAGCCCATGCCCAGGACATAGCAGGAGCCCCTCAACGTGGGTGAGACACTGTTCACCACAGAGCATTGCTGGGAGGACGGCTTGGG
Downstream sequence
tcctttgcccaatttttgatgggtttttttttttcttgtaaatctgttgaagttccttgtagattctatatattaggcctttgtcagatggatagattgc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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