VISDB Viral Integration Site DataBase

VIS ID

TVIS10013016

Fusion event

HBV-RASEF integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

precore/core protein|Core and e antigen|

Start

2156

Orient

+

Integrated sequence

ATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAGT| |AGTCAGTTATGTCAACACTAATATGGGCCTAAAGTTCAGGCAACTCTTGTGGTTTCACATTTCTTGTCTCACTTTTGGAAGAGAAACAGTTATAGAGTAT

Chromosome

chr9

Cytoband

q21.32

Reference genome

Start

End

85625266/83010351 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-21-5p ; hsa-mir-218-5p ; hsa-mir-5011-3p ; hsa-mir-5700 ; hsa-mir-4422 ; hsa-mir-5590-3p ; hsa-mir-142-5p ; hsa-mir-340-5p ; hsa-mir-6835-3p ; hsa-mir-497-5p ; hsa-mir-6838-5p ; hsa-mir-424-5p ; hsa-mir-195-5p ; hsa-mir-15a-5p ; hsa-mir-16-5p ; hsa-mir-15b-5p

Nearest miRNA

hsa-mir-101-2/Upstream/12200267; hsa-let-7a-1/Downstream/959397;

Nearest TSS

Nearest CpG islands

None/Target, chr9-CpG: 64/Upstream/1320265, chr9-CpG: 137/Downstream/51749

Upstream sequence

CTGGGAATATCTTGCCAAAAAACTATTACCTGCAGCTAcaaagtccagaatgtcaacttcttcagaacaaacagttcagtttctcccataaaaaatgcaa

Downstream sequence

ACCAATAACAGTTAAAAGAATGGAAGAGCAGCCCAGAGCATTCAAGTGACTTAAATGCACTTCTAGAAAGTGGAAACTGATGGAAATGTGTTGCCAAAGG