Basic Information
VIS ID
TVIS10013018
Fusion event
HBV-chrX integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|
Start
3008
Orient
+
Integrated sequence
TCCAGCCTTCAGAGCAAACACCGCAAATCCAGATTGGGACTTCAATCCCAACAAGGACACCTGGCCAGACGCCAACAAGGTAGGAGCTGGAGCATTCGGG| |CTGGGTTTCACCCCACCGCACGGAGGCCTTTTGGGGTGGAGCCCTCAGGCTCAGGGCATACTACAAACTTTGCCAGCAAATCCGCCTCCTGCCTCCACCA
Host Sequence
Chromosome
chrX
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
102278784/103023856 (Hg38)
End
102278784/103023856 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-let-7f-2/Upstream/7960630; hsa-mir-105-1/Downstream/3615958;
Nearest TSS
ENST00000429181/Upstream/83295; ENST00000372691/Downstream/40384;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/86218, chrX-CpG: 59/Downstream/39817
Nearby gene
RAB40AL(-85556) ; BEX1(+38797) ;
Upstream sequence
ggaagacgattcatccccaaaatctattgataagagtctggctagggcaacaccttaagtatgagatctgtaacagaggacccattagagcccccttaga
Downstream sequence
atttgctgaggagagctttacttccaactatgtggtcaattttggaataggtgtggtgtggtgttgaaaaaaatgtatattctgttgatttggggtggag
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate