Basic Information
VIS ID
TVIS10013020
Fusion event
HBV-chrX integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|
Start
2876
Orient
+
Integrated sequence
TTATATAAGAGAGAAACAACACATAGCGCCTCATTTTGTGGGTCACCATATTCTTGGGAACAAGATCTACAGCATGGGGCAGAATCTTTCCACCAGCAAT| |CCTCTGGGATTCTTTCCCGACCACCAGTTGGATCCAGCCTTCAGAGCAAACACCGCAAATCCAGATTGGGACTTCAATCCCAACAAGGACACCTGGCCAG
Host Sequence
Chromosome
chrX
Cytoband
q24
Reference genome
GRCh37/hg19
Start
119320365/120186512 (Hg38)
End
119320365/120186512 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-let-7f-2/Upstream/539664; hsa-mir-105-1/Downstream/1184460;
Nearest TSS
ENST00000429181/Upstream/27951; ENST00000557385/Downstream/64240;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/27027, chrX-CpG: 28/Downstream/58279
Nearby gene
RHOXF2B(-22420) ; NKAPP1(+49944) ;
Upstream sequence
atgcctgtaatcccagcactttgggaggcagatcacgaggtcaggagtttgagaccagcctggacaatatggtgaaaacccatctctactaaaaatacaa
Downstream sequence
cacaccacacctattccaaaattgaccacatagttggaagtaaagcactcctcagcaaatgtaaaagaacagaaattataacaaactgtctctcagacca
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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