Basic Information
VIS ID
TVIS10013022
Fusion event
HBV-chrX integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1821
Orient
+
Integrated sequence
TGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAA| |CTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATA
Host Sequence
Chromosome
chrX
Cytoband
q26.3
Reference genome
GRCh37/hg19
Start
134778649/135644724 (Hg38)
End
134778649/135644724 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-let-7f-2/Upstream/1098013; hsa-mir-105-1/Downstream/906154;
Nearest TSS
ENST00000429181/Upstream/64787; ENST00000594565/Downstream/68729;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/122522, chrX-CpG: 93/Downstream/328788
Nearby gene
INTS6L(-62189) ; CT45A1(+68536) ;
Nearest cancer related gene
CT45A1(OG, +68536) ;
Upstream sequence
AGGGCTCATCCCCTGTACATCAGCTAGCAGGTTGGCAGCAAGACCAATCCCAGGCTGTGGCTGCTGGAGGAACAGGAGAAATCATGGGTTTCTGCCTTGG
Downstream sequence
CACGATGAGCAGGGTGGATATTGTGGATGGAGGCCCAAAAAACAAAAACAAAAACCCAAATCATAATCTTAGACCTTTCAGCCAAGAAGGACTGATGATG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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