Basic Information
VIS ID
TVIS10013028
Fusion event
HBV-chrX integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|
Start
2910
Orient
+
Integrated sequence
TTTGTGGGTCACCATATTCTTGGGAACAAGATCTACAGCATGGGGCAGAATCTTTCCACCAGCAATCCTCTGGGATTCTTTCCCGACCACCAGTTGGATC| |CAGCCTTCAGAGCAAACACCGCAAATCCAGATTGGGACTTCAATCCCAACAAGGACACCTGGCCAGACGCCAACAAGGTAGGAGCTGGAGCATTCGGGCT
Host Sequence
Chromosome
chrX
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
80945606/81690107 (Hg38)
End
80945606/81690107 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-let-7f-2/Upstream/2788858; hsa-mir-105-1/Downstream/2535645;
Nearest TSS
ENST00000429181/Upstream/434613; ENST00000373200/Downstream/1818154;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/686113, chrX-CpG: 63/Downstream/1818456
Nearby gene
SH3BGRL(-391560) ; POU3F4(+1817663) ;
Upstream sequence
ggttagggttagggttagggttagggttagggttagggttagggttagggttagggttagggttagggttagggttagggttagggttagggttagggtt
Downstream sequence
atatacatttttttcaacaccacaccacacctattccaaaattgaccacatagttggaagtaaagcactcctcagcaaatgtaaaagaatggaaattata
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate