Basic Information
VIS ID
TVIS10013037
Fusion event
HBV-NEGR1-IT1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
332
Orient
+
Integrated sequence
TCACAATACCGCAGAGTCTAGACTCGTGGTGGACTTCTCTCAATTTTCTAGGGGGAACTACCGTGTGTCTTGGCCAAAATTCGCAGTCCCCAACCTCCAA| |TCACTCACCAACCTCTTGTCCTCCAACTTGTCCTGGTTATCGCTGGATGTGTCTGCGGCGTTTTATCATCTTCCTCTTCATCCTGCTGCTATGCCTCATC
Host Sequence
Chromosome
chr1
Cytoband
p31.1
Reference genome
GRCh37/hg19
Start
72270446/71804763 (Hg38)
End
72270446/71804763 (Hg38)
Orient
+
Location type
ncRNA_intronic
Fragile sites / regions
FRA1L
Target gene
NEGR1-IT1
Nearest miRNA
hsa-mir-101-1/Upstream/737047; hsa-mir-11399/Downstream/5255380;
Nearest TSS
ENST00000473358/Upstream/101358; ENST00000418078/Downstream/296154;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/723663, chr1-CpG: 55/Downstream/478563
Upstream sequence
tatgcctgtctttactttaatctcttaatcccatcatctttgtaaactgaggaggatgtatgttgcctcaggaccctgtgatgattgcattaactgcaca
Downstream sequence
aattgtttgtagagcatgtgtgtttgaacaatatgaaatctgggcaccttgaaaaaagaacaggataacagcaatgataagggaacaagagagataacct
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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