Basic Information
VIS ID
TVIS10013044
Fusion event
HBV-chr10 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1669
Orient
-
Integrated sequence
TGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCATGGAGACCACCGTGAACGCCCACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTT| |GGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCT
Host Sequence
Chromosome
chr10
Cytoband
p12.2
Reference genome
GRCh37/hg19
Start
23774750/23485821 (Hg38)
End
23774750/23485821 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-1265/Upstream/1989180; hsa-mir-107/Downstream/789864;
Nearest TSS
ENST00000439456/Upstream/46363; ENST00000481700/Downstream/208925;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/45227, chr10-CpG: 21/Downstream/207632
Nearby gene
OTUD1(-43440) ; KIAA1217(+208925) ;
Upstream sequence
gctttgtcgcccaggctggagtgcaatgtcgcgatgtcggctcactgcaagctccgcctcccgggttcacaccattctcctgcctcagcctcctgagtag
Downstream sequence
ctgggactacaggtgcccaccaccacacccggctaatttttttgtatttttagtagagacggggcttcactgtgttagccaggatggtctcgatctcctg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate