VISDB Viral Integration Site DataBase

VIS ID

TVIS10013056

Fusion event

HBV-MLXIP integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|

Start

1769

Orient

-

Integrated sequence

GGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCT| |TTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAA

Chromosome

chr12

Cytoband

q24.31

Reference genome

Start

End

122609794/122125247 (Hg38)

Orient

+

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-335-5p ; hsa-mir-98-5p ; hsa-mir-26b-5p ; hsa-mir-877-5p ; hsa-mir-421 ; hsa-mir-20a-5p ; hsa-mir-106b-5p ; hsa-mir-6858-5p ; hsa-mir-4689 ; hsa-mir-4710 ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-4763-3p ; hsa-mir-149-3p ; hsa-mir-1207-5p ; hsa-mir-6077 ; hsa-mir-6799-3p ; hsa-mir-3173-5p ; hsa-mir-4722-5p ; hsa-mir-1286 ; hsa-mir-873-5p ; hsa-mir-6804-5p ; hsa-mir-6133 ; hsa-mir-6130 ; hsa-mir-6129 ; hsa-mir-6127 ; hsa-mir-4510 ; hsa-mir-4419a ; hsa-mir-4784 ; hsa-mir-1827 ; hsa-mir-4756-5p ; hsa-mir-3150b-3p ; hsa-mir-4739 ; hsa-mir-1321 ; hsa-mir-940 ; hsa-mir-6893-5p ; hsa-mir-6808-5p ; hsa-mir-6873-5p ; hsa-mir-6856-5p ; hsa-mir-6758-5p ; hsa-mir-6816-3p ; hsa-mir-3941 ; hsa-mir-5689 ; hsa-mir-8064 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485 ; hsa-mir-4298 ; hsa-mir-1302 ; hsa-mir-561-5p ; hsa-mir-216b-3p ; hsa-mir-3922-5p ; hsa-mir-603 ; hsa-mir-5581-5p ; hsa-mir-4297 ; hsa-mir-5695 ; hsa-mir-662 ; hsa-mir-3614-3p ; hsa-mir-483-5p ; hsa-mir-6801-5p ; hsa-mir-1914-5p ; hsa-mir-4793-5p ; hsa-mir-383-3p ; hsa-mir-3065-3p ; hsa-mir-6871-3p ; hsa-mir-377-3p ; hsa-mir-4284 ; hsa-mir-342-3p ; hsa-mir-4714-3p ; hsa-mir-30e-5p ; hsa-mir-30d-5p ; hsa-mir-30c-5p ; hsa-mir-30b-5p ; hsa-mir-30a-5p ; hsa-mir-519d-3p ; hsa-mir-93-5p ; hsa-mir-20b-5p ; hsa-mir-17-5p ; hsa-mir-195-5p ; hsa-mir-16-5p ; hsa-mir-15a-5p ; hsa-mir-15b-5p ; hsa-mir-122-5p ; hsa-mir-1299 ; hsa-mir-1304-3p ; hsa-mir-140-3p ; hsa-mir-143-5p ; hsa-mir-150-3p ; hsa-mir-216a-5p ; hsa-mir-3135b ; hsa-mir-3652 ; hsa-mir-4430 ; hsa-mir-4476 ; hsa-mir-500b-3p ; hsa-mir-504-3p ; hsa-mir-5698 ; hsa-mir-6128 ; hsa-mir-6499-3p ; hsa-mir-6736-3p ; hsa-mir-6787-3p ; hsa-mir-6802-3p ; hsa-mir-6876-5p ; hsa-mir-6890-3p ; hsa-mir-875-3p ; hsa-mir-1182 ; hsa-mir-129-5p ; hsa-mir-193a-5p ; hsa-mir-3674 ; hsa-mir-4524a-3p ; hsa-mir-4524b-3p ; hsa-mir-4732-5p ; hsa-mir-6832-5p

Nearest miRNA

hsa-let-7i/Upstream/680895; hsa-mir-3612/Downstream/570660;

Nearest TSS

Nearest CpG islands

None/Target, chr12-CpG: 104/Upstream/788, chr12-CpG: 41/Downstream/57854

Upstream sequence

aagagcgaaactccatctccaaaaacaaacaaaaatttggctgatgtggtggtgggcacctgtagtcccagctactcggttggctgaggcggcagaatcg

Downstream sequence

cttgaagccaggaggcggaagttgcagtgagccaagatctcgccactgcactccagcctgggcaacagagcgagactccatctcaaaaaaaaaaaaaaTT