Basic Information
VIS ID
TVIS10013071
Fusion event
HBV-chr19 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|
Start
3095
Orient
-
Integrated sequence
TGGAGCATTCGGGCTGGGTTTCACCCCACCGCACGGAGGCCTTTTGGGGTGGAGCCCTCAGGCTCAGGGCATACTACAAACTTTGCCAGCAAATCCGCCT| |CCTGCCTCCACCAATCGCCAGTCAGGAAGGCAGCCTACCCCGCTGTCTCCACCTTTGAGAAACACTCATCCTCAGGCCATGCAGTGG
Host Sequence
Chromosome
chr19
Cytoband
q13.11
Reference genome
GRCh37/hg19
Start
34364347/33873442 (Hg38)
End
34364347/33873442 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA19A
Nearest miRNA
hsa-mir-10395/Upstream/13474088; hsa-let-7e/Downstream/1249258;
Nearest TSS
ENST00000633603/Upstream/59631; ENST00000610908/Downstream/32910;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/52830, chr19-CpG: 127/Downstream/32124
Nearby gene
KCTD15(-57681) ; LSM14A(+299005) ;
Upstream sequence
CCCATGCTCAGTCTTGATTTGGAATTCTCTTGGAAACATTGTTTATAATTGGCCATTCAGAACAACCTTAGTGCTTATAAAGCTGTCACCCATGTGGTCC
Downstream sequence
AGTCTCAGGTCAGTGTCTCAGACAAAGAACCTGAATCCATCAGCTTAAATGTAATTTCAAAGTCAGACAAGTTCAATCCTGCCATTTCTCAAACACTCTG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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