Basic Information
VIS ID
TVIS10013072
Fusion event
HBV-LIPE-AS1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
357
Orient
-
Integrated sequence
GTGGTGGACTTCTCTCAATTTTCTAGGGGGAACTACCGTGTGTCTTGGCCAAAATTCGCAGTCCCCAACCTCCAATCACTCACCAACCTCTTGTCCTCCA| |ACTTGTCCTGGTTATCGCTGGATGTGTCTGCGGCGTTTTATCATCTTCCTCTTCATCCTGCTGCTATGCCTCATCTTCTTGTTGGTTCTTCTGGACTATC
Host Sequence
Chromosome
chr19
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
43149243/42645091 (Hg38)
End
43149243/42645091 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA19A
Target gene
LIPE-AS1
Nearest miRNA
hsa-mir-10395/Upstream/293886; hsa-let-7e/Downstream/2008595;
Nearest TSS
ENST00000633603/Upstream/50036; ENST00000425668/Downstream/94281;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/220645, chr19-CpG: 20/Downstream/52856
Nearby gene
CEACAM8(-50161) ; PSG3(+76551) ;
Upstream sequence
CTTCCTTCCTCATCATTTTTGTAGCCCAGTGGTCCCCAAATGTGTTGTGGGTGCTGTGAAGACTCTTATCAAATTTTTTTTGTAGAGCTTTTAAAAAATA
Downstream sequence
TTTGTACCTGGCCATCACTAAGATGACCTTGAACTGAACTGAGTGCTTAGGGCTTTAAGGAGTTCAATTGAGATTTGTTTTTCCAAGAACACAACAAACT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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