Basic Information
VIS ID
TVIS10013077
Fusion event
HBV-CPS1-IT1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
1349
Orient
-
Integrated sequence
TTCGGCTCCTCTGCCGATCCATACTGCGGAACTCCTAGCCGCTTGTTTTGCTCGCAGCAGGTCTGGAGCAAACATTATCGGGACTGATAACTCTGTTGTC| |CTATCCCGCAAATATACATCGTTTCCATGGCTGCTAGGCTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTTTACGTCCCGTCGGCGCTGAATC
Host Sequence
Chromosome
chr2
Cytoband
q34
Reference genome
GRCh37/hg19
Start
211484038/210619314 (Hg38)
End
211484038/210619314 (Hg38)
Orient
+
Location type
ncRNA_exonic
Target gene
CPS1-IT1
Nearest miRNA
hsa-mir-10b/Upstream/2864433; hsa-mir-1244-1/Downstream/1806949;
Nearest TSS
ENST00000437798/Upstream/14349; ENST00000497121/Downstream/11914;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/142502, chr2-CpG: 86/Downstream/1918142
Upstream sequence
TGTGCATTGGAAGGAGCAGACTATGGAGCCAGAGATTGGTGCGCAGTCCTCCCCACTGTAGAATCAGACGTACATCACCTCTTTCATTTCTCCAGATTCA
Downstream sequence
TGTTCTTTCTCTTAATCTCTGCTTCTAGTTTTTTTGTGAAGCTTAATTTATATAAGTATAAATGACATCTGACATATTGTGAGGGCCCAAGAAAATTTTT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate