Basic Information
VIS ID
TVIS10013078
Fusion event
HBV-CPS1-IT1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|middle S protein|
Start
98
Orient
+
Integrated sequence
AATTCCACAACCTTCCACCAAACTCTGCAAGATCCCAGAGTGAGAGGCCTGTATTTCCCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCT| |GACTACTGCCTCTCCCTTATCGTCAATCTTCTCGAGGATTGGGGACCCTGCGCTGAACATGGAGAACATCACATCAGGATTCCTAGGACCCCTTCTCGTG
Host Sequence
Chromosome
chr2
Cytoband
q34
Reference genome
GRCh37/hg19
Start
211484051/210619327 (Hg38)
End
211484051/210619327 (Hg38)
Orient
-
Location type
ncRNA_exonic
Target gene
CPS1-IT1
Nearest miRNA
hsa-mir-10b/Upstream/2864446; hsa-mir-1244-1/Downstream/1806936;
Nearest TSS
ENST00000437798/Upstream/14362; ENST00000497121/Downstream/11901;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/142515, chr2-CpG: 86/Downstream/1918129
Upstream sequence
GAGCAGACTATGGAGCCAGAGATTGGTGCGCAGTCCTCCCCACTGTAGAATCAGACGTACATCACCTCTTTCATTTCTCCAGATTCATGTTCTTTCTCTT
Downstream sequence
AATCTCTGCTTCTAGTTTTTTTGTGAAGCTTAATTTATATAAGTATAAATGACATCTGACATATTGTGAGGGCCCAAGAAAATTTTTCCTCTTTTCCCCT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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