Basic Information
VIS ID
TVIS10013080
Fusion event
HBV-LOC105374584 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
332
Orient
+
Integrated sequence
TCACAATACCGCAGAGTCTAGACTCGTGGTGGACTTCTCTCAATTTTCTAGGGGGAACTACCGTGTGTCTTGGCCAAAATTCGCAGTCCCCAACCTCCAA| |TCACTCACCAACCTCTTGTCCTCCAACTTGTCCTGGTTATCGCTGGATGTGTCTGCGGCGTTTTATCATCTTCCTCTTCATCCTGCTGCTATGCCTCATC
Host Sequence
Chromosome
chr2
Cytoband
p21
Reference genome
GRCh37/hg19
Start
46870477/46643338 (Hg38)
End
46870477/46643338 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA2S
Target gene
LOC105374584
Nearest miRNA
hsa-mir-1301/Upstream/11171852; hsa-mir-10b/Downstream/734337;
Nearest TSS
ENST00000437798/Upstream/26187; ENST00000394861/Downstream/55614;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/26145, chr2-CpG: 116/Downstream/55421
Nearby gene
CRIPT(-17596) ; SOCS5(+55622) ;
Upstream sequence
ggttatctcccttgttccctgaaaatcactgttatcctgttcttttttaggatgcccagatttcatattattcaaacatatgtgttttacaaacaatttg
Downstream sequence
tgcagttaatgcaatcatcacagggtcctgaggcgacatacatcctcagcttacaaagatgatgggattaagagattaaagtaaagacaggcataggaaa
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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