Basic Information
VIS ID
TVIS10013083
Fusion event
HBV-chr20 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|middle S protein|
Start
83
Orient
+
Integrated sequence
AATTCCACAACCTTCCACCAAACTCTGCAAGATCCCAGAGTGAGAGGCCTGTATTTCCCTGCTGGTGGCTCCAGTTCAGGAAC| |AGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATCGTCAATCTTCTCGAGGATTGGGGACCCTGCGCTGAACATGGAGAACATCACATCAGGATTCCTA
Host Sequence
Chromosome
chr20
Cytoband
p12.1
Reference genome
GRCh37/hg19
Start
16035809/16055164 (Hg38)
End
16035809/16055164 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-103a-2/Upstream/5405469; hsa-mir-1-1/Downstream/2415451;
Nearest TSS
ENST00000382410/Upstream/69376; ENST00000616572/Downstream/315472;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/2058742, chr20-CpG: 50/Downstream/518027
Nearby gene
MACROD2(-1968) ; KIF16B(+216940) ;
Upstream sequence
CAAGGAGATAACTATACCAATATGCACTTCCCTTCCCCAgggaggattatacttcctcatcttactgaaattggatatggctgtgtaatttcctttgttc
Downstream sequence
aatatataggcagaaatggcatgtgtcacatcaggcagaagcatgaagactcacgctctattctttccccatggtaataaccagcaatatcccagacagg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate