VISDB Viral Integration Site DataBase

VIS ID

TVIS10013085

Fusion event

HBV-EWSR1 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

Polymerase|

Start

1293

Orient

-

Integrated sequence

GCAACCCCCACTGGCTGGGGCTTGGTCATGGGCCATCAGCGCATGCGTGGAACCTTTTCGGCTCCTCTGCCGATCCATACTGCGGAACTCCTAGCCGCTT| |GTTTTGCTCGCAGCAGGTCTGGAGCAAACATTATCGGGACTGATAACTCTGTTGTCCTATCCCGCAAATATACATCGTTTCCATGGCTGCTAGGCTGTGC

Chromosome

chr22

Cytoband

q12.2

Reference genome

Start

End

29693426/29297436 (Hg38)

Orient

-

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-let-7a-5p ; hsa-mir-877-3p ; hsa-mir-615-3p ; hsa-mir-423-3p ; hsa-mir-328-3p ; hsa-mir-362-5p ; hsa-mir-320a ; hsa-mir-149-5p ; hsa-mir-23b-3p ; hsa-mir-196a-5p ; hsa-mir-100-5p ; hsa-let-7c-5p

Nearest miRNA

hsa-mir-1286/Upstream/837488; hsa-let-7a-3/Downstream/709613;

Nearest TSS

Nearest CpG islands

None/Target, chr22-CpG: 279/Upstream/28522, chr22-CpG: 164/Downstream/8896

Nearest cancer related gene

EWSR1(OG, No orient, 0)

Upstream sequence

tagagatggggtttcaccatgttggtcaggctgTAGGAAGGTTTTTAAGTGTATTTAAGTATGGCCTTTTTCTggccaggcacagtggctcttgcctata

Downstream sequence

atcctaccacttcaggaggccaaggcaggaggattgtttgaaccaaggagttcactagcagcctgggcaacctagtgagacactgcctctacaaacaatt