Basic Information
VIS ID
TVIS10013086
Fusion event
HBV-NDUFA6-DT integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
332
Orient
+
Integrated sequence
TCACAATACCGCAGAGTCTAGACTCGTGGTGGACTTCTCTCAATTTTCTAGGGGGAACTACCGTGTGTCTTGGCCAAAATTCGCAGTCCCCAACCTCCAA| |TCACTCACCAACCTCTTGTCCTCCAACTTGTCCTGGTTATCGCTGGATGTGTCTGCGGCGTTTTATCATCTTCCTCTTCATCCTGCTGCTATGCCTCATC
Host Sequence
Chromosome
chr22
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
42491476/42095472 (Hg38)
End
42491476/42095472 (Hg38)
Orient
+
Location type
ncRNA_intronic
Fragile sites / regions
FRA22A
Target gene
NDUFA6-DT
Nearest miRNA
hsa-mir-1281/Upstream/172175; hsa-let-7a-3/Downstream/3105482;
Nearest TSS
ENST00000624155/Upstream/4517; ENST00000626627/Downstream/34437;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/4230, chr22-CpG: 95/Downstream/33257
Upstream sequence
tttcctattcctgtctttaatctcttaatcccgtcatcttcgtaagctgaggaggatgtatgtcgcctcaggaccctgtgatgattgcattaactgcaca
Downstream sequence
aattgtttgtagagcatgtgtgtttgaataatatgaaatctgggcaccttgaaaaaagaacaggataacagcaacgttcagggaacaagagagataacct
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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