VISDB Viral Integration Site DataBase

VIS ID

TVIS10013088

Fusion event

HBV-SETD2 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|

Start

1762

Orient

-

Integrated sequence

GACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTA| |AAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTAC

Chromosome

chr3

Cytoband

p21.31

Reference genome

Start

End

47143721/47102231 (Hg38)

Orient

-

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-106b-5p ; hsa-mir-26a-5p ; hsa-mir-199b-5p ; hsa-mir-21-5p ; hsa-mir-186-5p ; hsa-mir-526b-3p ; hsa-mir-199a-5p ; hsa-mir-1289 ; hsa-mir-3198 ; hsa-mir-3658 ; hsa-mir-3667-5p ; hsa-mir-4294 ; hsa-mir-4309 ; hsa-mir-4726-3p ; hsa-mir-5702

Nearest miRNA

hsa-mir-12127/Upstream/2240250; hsa-let-7g/Downstream/747324;

Nearest TSS

Nearest CpG islands

None/Target, chr3-CpG: 148/Upstream/92112, chr3-CpG: 172/Downstream/61068

Nearest cancer related gene

SETD2(TSG, No orient, 0)

Upstream sequence

AGAGCTAAGGAGCCACCACGCGGAGCGCAGACCACAGCACAGCATTTTGAAtggctgcttgggtctacctgaggagcctagaaaaatacagatacccagg

Downstream sequence

taagggacactgtacagtgagagtctcacagctagacatgtggccaccagctctggcagaactataaccaaaacctaggttgaatgattccacagtaggt