Basic Information
VIS ID
TVIS10013089
Fusion event
HBV-chr3 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
332
Orient
+
Integrated sequence
TCACAATACCGCAGAGTCTAGACTCGTGGTGGACTTCTCTCAATTTTCTAGGGGGAACTACCGTGTGTCTTGGCCAAAATTCGCAGTCCCCAACCTCCAA| |TCACTCACCAACCTCTTGTCCTCCAACTTGTCCTGGTTATCGCTGGATGTGTCTGCGGCGTTTTATCATCTTCCTCTTCATCCTGCTGCTATGCCTCATC
Host Sequence
Chromosome
chr3
Cytoband
p21.31
Reference genome
GRCh37/hg19
Start
49180625/49143192 (Hg38)
End
49180625/49143192 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-12127/Upstream/43278; hsa-let-7g/Downstream/130928;
Nearest TSS
ENST00000440867/Upstream/10074; ENST00000476495/Downstream/23129;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/22162, chr3-CpG: 57/Downstream/22660
Nearby gene
LAMB2(-10026) ; LAMB2P1(+9667) ;
Upstream sequence
CCTTTTTATTAATATTTCAGCCACAAAATTAAAAAAAAACTTTCTCAGGATTAAATTATTTTTATTAAGTTCTCATGTCTGATTCTGTTCTAGGTACTAT
Downstream sequence
tgcagttaatgcaatcatcacagggtcctgaggcgacatacatcctcctcagtttacgagatgacaggattaagatattaaagtaaagacaggcatagga
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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