Basic Information
VIS ID
TVIS10013090
Fusion event
HBV-chr3 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1806
Orient
-
Integrated sequence
ACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGC| |ACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGG
Host Sequence
Chromosome
chr3
Cytoband
p21.2
Reference genome
GRCh37/hg19
Start
51894145/51860129 (Hg38)
End
51894145/51860129 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-12127/Upstream/1184966; hsa-let-7g/Downstream/408149;
Nearest TSS
ENST00000440867/Upstream/30299; ENST00000429548/Downstream/1500;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/144084, chr3-CpG: 80/Downstream/81467
Nearby gene
IQCF3(-29271) ; IQCF2(+1500) ;
Upstream sequence
TTAATTGGGCCTGATCTGACTGGATCATTACTGATACGATGAGCTTTGAGACCTCTCTGAGAGGCTGGCTGCTCCCTTCCCCAGAGGTTAGTGCTCAGCT
Downstream sequence
aaaagaatgaatttgaacctagcctcactccatacacaaaacttaaaatggatcaaagatctaaatgtaagagctaaagctataaaactcttagaaTTTT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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