Basic Information
VIS ID
TVIS10013092
Fusion event
HBV-STIMATE integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2046
Orient
+
Integrated sequence
ACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGT| |TCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTA
Host Sequence
Chromosome
chr3
Cytoband
p21.1
Reference genome
GRCh37/hg19
Start
52872856/52838840 (Hg38)
End
52872856/52838840 (Hg38)
Orient
-
Location type
UTR3
Target gene
STIMATE
Nearest miRNA
hsa-let-7g/Upstream/544532; hsa-mir-12124/Downstream/7623;
Nearest TSS
ENST00000440867/Upstream/3111; ENST00000477794/Downstream/1422;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/67728, chr3-CpG: 72/Downstream/58370
Upstream sequence
tgcccatgataaggctatgtgaaaggtacagctgaagagagagttgacgaattaggtccaatatggcaacctgccacaCCTGAGGATACAAAACAGCACA
Downstream sequence
TGCTCATGCAGGTCTAAAAGGAAGGTCCTAAGTGGAGTGGCCTCCTCTGCACTTGTCTCACTTGAAGTCCAGGATGTCTCCCTTCTAGCTCATCACACCT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate