Basic Information
VIS ID
TVIS10013095
Fusion event
HBV-chr3 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1816
Orient
-
Integrated sequence
CTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCA| |TGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCC
Host Sequence
Chromosome
chr3
Cytoband
p12.3
Reference genome
GRCh37/hg19
Start
74183520/74134369 (Hg38)
End
74183520/74134369 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-let-7g/Upstream/2592280; hsa-mir-12124/Downstream/1080107;
Nearest TSS
ENST00000440867/Upstream/134564; ENST00000608707/Downstream/133170;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/509145, chr3-CpG: 86/Downstream/479986
Nearby gene
PDZRN3(-509448) ; CNTN3(+128202) ;
Upstream sequence
CCAGTGAATTTAATTGGGCCTGATCTGACTGGATCATTACTGATACGATGAGCTTTGAGACCTCTCTGAGAGGCTGGCTGCTCCCTTCCCCAGAGGTTAG
Downstream sequence
cataaaaattaaaaATAAAACATTTTTTTAAATGCACTGAAATTTCCTCCAGATATCTAATCTCCACCTGCCCTAAACAAATTATTCTCTCCATCAGTAA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate