VISDB Viral Integration Site DataBase

VIS ID

TVIS10013096

Fusion event

HBV-ROBO2 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|Polymerase|

Start

1450

Orient

-

Integrated sequence

TATCCCGCAAATATACATCGTTTCCATGGCTGCTAGGCTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTTTACGTCCCGTCGGCGCTGAATCC| |TGCGGACGACCCTTCTCGGGGTCGCTTGGGACTCTCTCGTCCCCTTCTCCGTCTGCCGTTCCGACCGACCACGGGGCGCACCTCTCTTTACGCGGACTCC

Chromosome

chr3

Cytoband

p12.3

Reference genome

Start

End

77572641/77523490 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-145-5p ; hsa-mir-342-5p ; hsa-mir-514b-3p ; hsa-mir-514a-3p ; hsa-mir-6844 ; hsa-mir-4801 ; hsa-mir-4731-3p ; hsa-mir-8084

Nearest miRNA

hsa-let-7g/Upstream/1785127; hsa-mir-12124/Downstream/1984397;

Nearest TSS

Nearest CpG islands

None/Target, chr3-CpG: 148/Upstream/425242, chr3-CpG: 49/Downstream/1495423

Upstream sequence

TTAATTGGGCCTGATCTGACTGGATCATTACTGATACGATGAGCTTTGAGACCTCTCTGAGAGGCTGGCTGCTCCCTTCCCCAGAGGTTAGTGCTCAGCT

Downstream sequence

CACTTTCTGGGTGTCATGCACTTCCTCAGTCATGGAATAATGTTCATTTATAGACTCCCTGGAATTGCTTATAAGTGAAAGAAAGCATTACTTAACTTCA