Basic Information
VIS ID
TVIS10013099
Fusion event
HBV-chr4 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
2492
Orient
+
Integrated sequence
GCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAGGTGGGGAACTTTACTGGGC| |TTTATTCTTCTACTGTACCTGTCTTTAATCCTCATTGGAAAACACCATCTTTTCCTAATATACATTTACACCAAGACATTATCAAAAAATGTGAACAGTT
Host Sequence
Chromosome
chr4
Cytoband
q31.21
Reference genome
GRCh37/hg19
Start
144161919/143240766 (Hg38)
End
144161919/143240766 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-12113/Upstream/17733459; hsa-mir-1305/Downstream/102694;
Nearest TSS
ENST00000502981/Upstream/55072; ENST00000512715/Downstream/45527;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/55087, chr4-CpG: 158/Downstream/95012
Nearby gene
USP38(-18778) ; GAB1(+96064) ;
Upstream sequence
tgataggagcaccaaccctattataaactgcatgtggaagtgatctaggttgtgtgctccttatgagaatctaatgcctgatgatctgtcactgtttccc
Downstream sequence
GCTTCCTCTCTTTTCTCCTGCTCTCTCCTGTTACTCTGCAACACCTTCACTCTACTCTGAGTGGAAGGGCCCACTGCTTTCTATATTACCCTCAAGGACC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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