Basic Information
VIS ID
TVIS10013102
Fusion event
HBV-LOC105377552 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
332
Orient
+
Integrated sequence
TCACAATACCGCAGAGTCTAGACTCGTGGTGGACTTCTCTCAATTTTCTAGGGGGAACTACCGTGTGTCTTGGCCAAAATTCGCAGTCCCCAACCTCCAA| |TCACTCACCAACCTCTTGTCCTCCAACTTGTCCTGGTTATCGCTGGATGTGTCTGCGGCGTTTTATCATCTTCCTCTTCATCCTGCTGCTATGCCTCATC
Host Sequence
Chromosome
chr4
Cytoband
q34.1
Reference genome
GRCh37/hg19
Start
175950024/175028873 (Hg38)
End
175950024/175028873 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC105377552
Nearest miRNA
hsa-mir-12113/Upstream/605009; hsa-mir-1305/Downstream/7140420;
Nearest TSS
ENST00000502981/Upstream/49492; ENST00000514864/Downstream/374237;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/199440, chr4-CpG: 26/Downstream/972449
Nearby gene
ADAM29(-50693) ; GPM6A(+604064) ;
Upstream sequence
atatctacccaaagggaaataagtcattacatcaaaaagacacctacatgcatctgtttattgcagcacaatttcaaagatatggaaccaatctaagtac
Downstream sequence
tgcagttaatgcaatcatcacagggtcctgaggtggcatacatcctcctcagcttatgaagaggacaggattaagaaattagagtaaagacaggcatagg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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