VISDB Viral Integration Site DataBase

VIS ID

TVIS10013104

Fusion event

HBV-PPARGC1A integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|

Start

1765

Orient

-

Integrated sequence

TCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAG| |GTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGT

Chromosome

chr4

Cytoband

p15.2

Reference genome

Start

End

24375129/24373506 (Hg38)

Orient

+

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-23a-3p ; hsa-mir-335-5p ; hsa-mir-98-5p ; hsa-mir-421 ; hsa-mir-425-3p ; hsa-mir-378a-5p ; hsa-let-7b-5p ; hsa-mir-130b-3p ; hsa-mir-1277-5p ; hsa-mir-6083 ; hsa-mir-190a-3p ; hsa-mir-4775 ; hsa-mir-3124-3p ; hsa-mir-5011-5p ; hsa-mir-32-3p ; hsa-mir-5585-3p ; hsa-mir-3941 ; hsa-mir-8064 ; hsa-mir-4789-3p ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485 ; hsa-mir-485-3p ; hsa-mir-485-5p ; hsa-mir-130a-3p ; hsa-mir-4311 ; hsa-mir-4524a-3p ; hsa-mir-4524b-3p ; hsa-mir-4668-5p

Nearest miRNA

hsa-mir-12113/Upstream/1858121; hsa-mir-1243/Downstream/146686;

Nearest TSS

Nearest CpG islands

None/Target, chr4-CpG: 46/Upstream/1857081, chr4-CpG: 266/Downstream/96571

Nearby gene

PPARGC1A(-483429) ; MIR573(+146686) ;

Upstream sequence

ggcatcaggccagtgcccctctgagacgaagtttccagaggaaggagcaggcagcaatctttgctgttctgtatcctccactggtgataaccaggcgaac

Downstream sequence

tcatttctaggctcttccctgtatatttctgcagactgcaaatctataatgaataaaaatgtctcttactatcagaaaacaaaTTGAAAGGAAGAAATGA