Basic Information
VIS ID
TVIS10013108
Fusion event
HBV-UGT2B26P integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
332
Orient
+
Integrated sequence
TCACAATACCGCAGAGTCTAGACTCGTGGTGGACTTCTCTCAATTTTCTAGGGGGAACTACCGTGTGTCTTGGCCAAAATTCGCAGTCCCCAACCTCCAA| |TCACTCACCAACCTCTTGTCCTCCAACTTGTCCTGGTTATCGCTGGATGTGTCTGCGGCGTTTTATCATCTTCCTCTTCATCCTGCTGCTATGCCTCATC
Host Sequence
Chromosome
chr4
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
69899851/69034133 (Hg38)
End
69899851/69034133 (Hg38)
Orient
+
Location type
Intronic
Target gene
UGT2B26P
Nearest miRNA
hsa-mir-12113/Upstream/2757205; hsa-mir-1243/Downstream/7539435;
Nearest TSS
ENST00000502981/Upstream/82342; ENST00000502942/Downstream/17230;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/683930, chr4-CpG: 55/Downstream/1654004
Nearby gene
UGT2B10(-13738) ; UGT2B7(+62342) ;
Upstream sequence
tagtttgattgcactgtggtctgagagacagttagttataatttctgttcttttacatttgctgaggagtgctttacttccaactatgtggtcaattttg
Downstream sequence
aattgtttgtaaagcatgtgtgttagaaaaatatgaaatctgggcaccttgaaaaaagaacaggataacagcaatgttcagggaacaagggagataaaca
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate