Basic Information
VIS ID
TVIS10013111
Fusion event
HBV-LINC02107 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
1915
Orient
+
Integrated sequence
ATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACC| |CTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTA
Host Sequence
Chromosome
chr5
Cytoband
p13.2
Reference genome
GRCh37/hg19
Start
38068465/38068363 (Hg38)
End
38068465/38068363 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA5A
Target gene
LINC02107
Nearest miRNA
hsa-mir-10397/Upstream/1920375; hsa-mir-103a-1/Downstream/489139;
Nearest TSS
ENST00000502646/Upstream/42666; ENST00000508853/Downstream/80117;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/227739, chr5-CpG: 104/Downstream/189419
Nearby gene
GDNF(-228683) ; EGFLAM(+190046) ;
Upstream sequence
acacaatcatagctcactgcagccttgaacttctgggctcaagcgatcttccagcctcagcatcagagaagctaggactacaggcatgcaccaccatggg
Downstream sequence
CAGAGCTGTCAACTGCTAGACAGCTTTTGCAGCCACTCTTCTGCACATCTCAATACTAAAGAGAGGGTCACTTTCAACTGGCACATTTAATAATGTCACC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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